in mice. GsMTx4 suppresses neurogenesis and improves astrogenesis in human neural stem cells. Technological Knowledge

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建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。

GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved with the ache reaction. GsMTx4 decreases the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells. GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo

GsMTx4 is actually a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels. GsMTx4 blocks stretch-activated cation channels in astrocytes, cardiac cells, and sleek and skeletal muscle cells.

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A regulatory position of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts through orthodontic tooth movement.

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